Jan Gettemans
- Full Professor
- Head of the Nanobody lab
Contact
Campus Ardoyen, Technologiepark-Zwijnaarde 75, 9052 Ghent
E-mail | LinkedIn | UGent Research Explorer | Orcid
Personalia
Biography
- 2004 - present: Professor - Ghent University
- 1993 - 2004: Postdoc - Ghent University
- 1993: PhD - Ghent University
- 1989: Master Biochemistry and Molecular Biology - Ghent university
Member of
Research tracks
Expertise
- Nanobody
- Protein expression and purification
- Actin binding proteins
- Click chemistry
- Fluorescent labelling
- Cancer cell invasion
- Cytoskeleton
Publications
Key publications
- Nuclear fascin regulates cancer cell survival. (2022) Elife.
- An AKT2-specific nanobody that targets the hydrophobic motif induces cell cycle arrest, autophagy and loss of focal adhesions in MDA-MB-231 cells. (2021) Biomed Pharmacother.
- α-Actinin-4 Promotes the Progression of Prostate Cancer Through the Akt/GSK-3β/β-Catenin Signaling Pathway. (2020) Frontiers in Cell and Developmental Biology.
- Cortactin and fascin-1 regulate extracellular vesicle release by controlling endosomal trafficking or invadopodia formation and function. (2018) Scientific Reports.
- Inhibitory cortactin nanobodies delineate the role of NTA- and SH3-domain-specific functions during invadopodium formation and cancer cell invasion. (2017) FASEB Journal.