Karolien De Bosscher
- Full Professor
- Head of the Translational Nuclear Receptor lab
Contact
Campus Ardoyen, Technologiepark-Zwijnaarde 75, 9052 Ghent
E-mail | LinkedIn | UGent Research Explorer | Orcid
Personalia
Biography
- 2013 - present: Professor - Ghent University
- 2002 - 2013: Postdoc - Ghent University
- 2000 - 2002: Postdoc - Cancer Research UK (London)
- 2000: PhD - Ghent University
- 1995: Master Biochemistry - Ghent University
Member of
- VIB-UGent Center for Medical Biotechnology
- Cancer Research Institute Ghent
- Nuclear Receptor Research Network
- UGent DiscoverE
Research tracks
Expertise
- Cellular signal transduction
- Anti-inflammatory and anti-cancer action mechanisms of nuclear receptors (GR, PPARs, ERRs)
- Selective glucocorticoid receptor modulation
- Metabolic actions of GR and PPAR
- Nuclear receptor crosstalk mechanisms (GR,MR) in hematological cancers.
- Assay development for nuclear receptors
Publications
Key publications
- Nuclear Receptors Shape Sepsis Pathophysiology. (2026) Endocrine Reviews.
- Modeling of glucocorticoid resistance in multiple myeloma reveals mechanisms and markers of glucocorticoid resistance. (2025) Biomedicine & Pharmacotherapy.
- CCR1 inhibition sensitizes multiple myeloma cells to glucocorticoid therapy. (2025) Pharmacological Research.
- PPARα-ERRα crosstalk mitigates metabolic dysfunction-associated steatotic liver disease progression. (2025) Metabolism: Clinical and Experimental.
- Exploring protein conformations with limited proteolysis coupled to mass spectrometry. (2024) Trends in Biochemical Sciences.
- Crosstalk interactions between transcription factors ERRα and PPARα assist PPARα-mediated gene expression. (2024) Molecular Metabolism.
- Glucocorticoid receptor signaling: intricacies and therapeutic opportunities. (2024) Trends in Biochemical Sciences.