Sudip Ghosh

CV

Sudip earned his Master of Science in Chemistry from the Indian Institute of Science (IISc), Bangalore, in 2020. He then worked as a research scholar in the Department of Organic Chemistry at IISc, where he gained expertise in peptide chemistry.

Currently, he is pursuing a PhD in organic chemistry in the OBCR group under the supervision of Prof. Annemieke Madder. Sudip is appointed as one of the OBCR group members in the interuniversity SOCan Project.

His research focuses on using furan cross-linking methods to covalently trap cancer nucleic acid biomarkers. Key areas include the synthesis of furan-modified nucleoside building blocks and oligonucleotides, as well as their use in the photo-electrochemical detection of the biomarkers of interest.

Research Project

Design of capture and detection probes for photo-electrochemical detection of cancer nucleic acid biomarkers

My PhD project is part of the interuniversity iBOF research project SOCan, which aims to develop a ground-breaking photoelectrochemistry-based ‘SOCan technology’ for the fast detection of clinically relevant levels of nucleic acid cancer biomarkers in patient samples. SOCan will address these bottlenecks in current molecular testing methods by developing, optimizing and validating an innovative solution to detect DNA alterations and RNA, selectively and specifically. The technology relies on singlet oxygen-based photoelectrochemistry and combines (i) photosensitizers that produce singlet oxygen upon illumination; (ii) capture and detection probes; (iii) redox reporters; and (iv) magnetic beads for immobilization and enhancing sensitivity. Such a platform is highly sensitive, robust, fast, easy to setup and allows for re-use. My specific task is concerned with the development of optimized capture probes that allow highly selective and sensitive detection of a specific target nucleic acid biomarker.