Doctoral fellow

Last application date
Aug 15, 2022 00:00
Department
GE31 - Department of Biomolecular Medicine
Contract
Limited duration
Degree
Master of Science in Biomedical Engineering, Master of Science in Biomedical Sciences, Master of Science in Biochemistry and Biotechnology, Master of Medicine in Medicine
Occupancy rate
100%
Vacancy type
Research staff

Job description

Applications are invited for a 4-year PhD fellowship, which will be conducted at the Center for Medical Genetics, Ghent University Hospital, Belgium.

The research project focusses on the study of molecular mechanisms underlying a group of inherited conditions caused by defects in five different enzymes necessary for proper assembly of the proteoglycan linker region and which are collectively called “linkeropathies”. In this project, knock-in zebrafish models will be generated and phenotypically characterized. Several genetic, transcriptomic, proteomic and glycomic approaches will be combined on relevant tissues to investigate and elucidate molecular pathways that are shared and/or different between these conditions to obtain a better understanding of the underlying disease mechanisms.
Principal investigators on the project are at Ghent University are Prof. Dr. Fransiska Malfait (see https://biblio.ugent.be/person/801001472639) and Dr. Delfien Syx (see https://biblio.ugent.be/person/802000427644).

We are looking for an enthusiastic and collaborative candidate who is dedicated to take advantage of a wide range of available resources. We offer a PhD training in a stimulating scientific environment. You will be registered in a Doctoral Schools program and will be able to attend the associated courses. You will have access to state-of-the-art research facilities and will be guided on a daily basis by well-trained professionals and get a thorough training in scientific thinking, practice, presentation and writing. The candidate will be encouraged and guided to apply for a personal fellowship. The default start date is October 1, 2022, but there is some flexibility.

Job profile

  • You have a good background in basic sciences.
  • You are willing to learn and adopt a variety of techniques of genetics, biochemistry, molecular biology and cell biology.
  • You have (or are willing to obtain) a Felasa C certificate to work with laboratory animals.
  • You have excellent oral and written communication skills and have a good knowledge of English.
  • You are willing to stay abroad for some time to acquire new skills.
  • You aim for perfection and are practically skillful.
  • You are ambitious, inventive and have a long-term vision.
  • You are willing and capable to work as a team member.

How to apply

Applications including a CV, motivation letter and a copy of your study results should be sent electronically to Prof. Dr. Fransiska Malfait (Fransiska.Malfait@Ugent.be) and Dr. Delfien Syx (Delfien.Syx@Ugent.be). Please mention “PhD linkeropathies” in the subject line of your email.
Preselected candidates will be invited for a (virtual) interview.
Starting date will be determined in agreement with the candidate.