Lezing 'Gasdermin-mediated pyroptosis: from antibacterial to antitumor immunity'
- Voor wie
- Alumni , Bedrijven , Medewerkers
- Wanneer
- 22-04-2024 van 10:00 tot 11:30
- Waar
- UGent-VIB-onderzoeksgebouw, Technologiepark 71, 9052 Zwijnaarde
- Voertaal
- Engels
- Door wie
- IRC-UGent-VIB
- Contact
- ruth.vanlaere@ugent.be
- Website
- https://www.irc.ugent.be/events
Dr. Feng Shao is known worldwide as a top scientist in the field of pyroptosis research; he will talk about Gasdermina, pore-forming proteins.
Gasdermina are pore-forming proteins conserved from humans to bacteria and execute pyroptosis to stimulate immune responses. GSDMD is cleaved/activated by canonical inflammasome-stimulated caspase-1 and cytosolic LPS-ligated caspase-4/5/11.
I will present the finding that LPS-activated caspase-4/5, but not mouse caspase-11, processes IL-18 in vitro and during bacterial infections, which mainly operates in epithelial cells. LPS-activated caspase-4/11, when occurring in brain endothelial cells, mediates BBB breakdown in response to circulating LPS or during LPS-induced sepsis.
Lastly, I will discuss the role of pyroptosis in stimulating antitumor immunity. Specifically, cytotoxic lymphocytes kill GSDMB-positive cells through pyroptosis, mediated by granzyme A cleavage of GSDMB. IFN-g upregulates GSDMB and promotes pyroptosis of cancer cells including that by CAR-T/TCR-T cells.